Method for promoting the growth of livestock

ABSTRACT

3-DI(HYDROXYMETHYL) AMINO - 6(5-NITRO - 2-FURYLETHENYL)- 1,2,4-TRIAZINE IS VERY EFFECTIVE FOR PROMOTING THE GROWTH OF LIVESTOCK (FOR EXAMPLE, POULTRY, DUCKS, TURKEYS, SWINE, HORSES, CATTLE AND GOATS) WHEN GIVEN TO THE LIVESTOCK IN COMBINATION WITH CARRIERS SUCH AS FEEDS AND INERT MINERALS.

United States Patent C) 3,704,335 METHOD FOR PROMOTING THE GROWTH OF LIVESTOCK Yutaka Kodama and Akira Takai, Toyama-shi, and

3,704,335 Patented Nov. 28, 1972 weight of PF-S. For example, such a very small dose of PF-S as 0.0002 to 0.001 percent by weight based on the feedstulf promotes the growth of chicks, and an increase of weight of the male chicks for broilers. This Tatsumi Iuagaki, Tokyo, Japan, assignors to Toyama is a remarkable feature of the present invention. Chemical Co., Ltd., Tokyo, Japan The growth-promoting effect on rats is shown in the No Drawing. Filed July 25, 1969, Ser. No. 845,053 following Table I as a fundamental test.

Int. Cl. A61k 27/00 TABLE I US. Cl. 424-249 4 Claims Average Increase of average bodyi logy; weigiltlggiesrtceig) after Avgrgge ABSTRACT OF THE DISCLOSURE $5003.. a weigh adminis- 1 3 4 after test 3-d1(hydroxymethyl)am1no 6-(5-n1tro 2-furylethent ati0n(g-) we we s we s w s (a) yl)-1,2,4-triazine is very eflective for promoting the Contrast growth of livestock (for example, poultry, ducks, turkeys, p 160 11 18 23 40 225 swine, horses, cattle and goats) when given to the livegroupz 155 17 29 44 63 255 stock in combination with carriers such as feeds and 120 rats are usedin each contrast and pinert minerals 3 PF-S is added only the feed in an amount 010.0005 percent by weight.

As clearly shown in the above table, PF-S can be ap- The present invention relates to a growth promoting preciatively efiective for increasing of the body-weight composition for livestock, and more particularly to the ig fi 1 th h t composition comprising as an efl ective ingredient 3-di(hy- E o owmg examp "i l ustrate 6 P droxymethyl)amino 6 (s nitm 2 fury1etheny1) 1,2,4 ing e ects of the composition of the present invention. triazilm EXAMPLE 1 It has been known that a certain nitrofuran derivative A breeding test was carried out using 40 male White such as 3-(5-nitro-2-furfurylideneamino)-oXazolidin-2- Leghorn chicks in each test group. There were four test one or 5-nitro-2-furyl acrylic acid amide or 5-nitro-2- groups, that is, a contrast, PF-S 2 mg. per 1 kg. of feed, furfural semicarbazone promotes the growth of livestock, PF-S 5 mg. per 1 kg. of feed and PF-S 10 mg. per 1 kg. for example, poultry, ducks, turkeys, swine, horses, cattle of feed, respectively. The chicks in each group were furand goats at the growing stage. 30 ther divided into smaller groups of 10 chicks each and The object of the present invention is to provide a bred according to the battery method for 9 weeks. The new nitrofuran-type growth-promoting composition for results are shown by body-weight of each 20 chicks in livestock. Table H.

TABLE It Average Body-weight of 20 chicks after increase administration of weight Average as com- Betore 1 3 5 7 9 increase pared with adminisweek weeks week weeks week of weight contrast Group tration (g.) (g.) (g.) (g.) (g.) (times) (percent) Contrast. 735 1,211 4,499 9,130 13,005 17, 571 23.9 100 "En According to the invention, there is provided a growth- From the above results, it was appreciated that a bodypromoting composition for livestock, which comprises weight increase of 5 to 12% based on the contrast was an inert carrier and 3-di(hydroxymethyl)amino-6-(5- obtained after 9 weeks by giving a feed containing nitro-2-furylethenyl)-1,2,4-triazine of the formula PF-S in the indicated amounts. When the body-weight increase in each small group was inspected during 3 to l CHzOH 5 weeks brecding, some groups showed more than 20 OZN percent increase as compared with the contrast small 0 55 group, and the other small groups also showed, 1n gen- CHZOH eral, superior results as compared with the increase ratio h drox meth 1 0 lethem after 9 weeks. demonstrates that PF-S is more ylyhzfpgriazige g z g z hergiflafter as P111) is 3 effective 1n the initial breed ng of ch1cks rather than tasfless, odorless, yellow crystalline powder and may in the later course of breeding where weight increase be prepared by the method described in Chemical ratio decreases and approximates to that of the contrast. Stracts 63, 163700 (1965) The composition of the The anatomic mspectlon of chlcks after the breeding present invention comprises an effective amount of showed no differences in the meat quality between the S as an effective ingredient and a carrier or diluent such contrast and groups as common feeds, minerals, wheat flour, soybean fluor EXAMPLE 2 and corn fluor which are 1116111 to PF-S.

The growth of livestock can be promoted or an in- Six two-month-old uterine Yorkshire pigs having a crease in the body-Weight thereof can be achieved when body-weight of 9.8 to 14.3 kg. individually were divided the composition is given repeatedly to the livestock at into a contrast group involving 3 pigs and a PF-S group the growing stage. The dose of PF-S varies according involving 3 pigs. The pigs were bred for 60 days by to the kind of growing stage of the livestock. In general, allowing them to feed at will on a powdered which con- PF-S is given to the livestock in the form of a mixture of a feed containing 0.0002 to 0.005 percent by tained in the PF-S group the compound in an amount of 5 mg. per 1 kg. thereof.

The results are shown in the following Table III. ethenyl)-1,2,4-triazine in an amount of from 0.0002 to TABLE III Average body- Final weight average Ratio of before bodyincrease Period breedin weight Increase [B]I[A] Index of (day) [A] (kg. (kg) [B] (kg.) (percent) increase PF-S group, mg./

g. (3 pigs) 60 11. 249 25. 577 14. 328 1. 27 128 Contrast group (3 pigs) 60 12. 178 24. 200 12. 022 0. 99 100 From the above table, it will be appreciated that .pigs given PF-S show a remarkable weight improvement as compared with those of the contrast group.

No detrimental side efiects of the compound or unwillingness of the pigs to take the feed was seen in the PF-S group. In addition, there were no contracted pigs in the PF-S group, while occurrence of loose-passage and scours was seen in two pigs belonging to the contrast group, respectively.

What is claimed is:

l. The method of promoting the growth of livestock selected from the group consisting of swine and poultry at the growing stage which comprises feeding said livestock a composition comprising an inert carrier and a growth-promoting effective amount of 3-di(hydroxymethyl) amino-'6-(5-nitro-2 furyl-ethenyl)-1,2,4-triazine.

2. The method of claim 1, wherein the composition comprises 3-di(hydroxymethyl)amino-6-(5-nitro-2-furylethenyl)-1,2,4-triazine in an amount of from 0.0002 to 0.005 percent by weight based on the total weight of the composition. I

3. The method of claim 1, wherein the composition comprises 3-di(hydroxymethyl)amino-6-(S-nitro-Z-furyl- References Cited UNITED STATES PATENTS 3,151,110 9/1964 Kodama et a1. 260-2495 3,153,648 10/1964 Kodama et a1. 260-2495 FOREIGN PATENTS 13,790 1954 Japan 424249 OTHER REFERENCES Japanese Patent Abstracts, 21528/64.

Chemical Abstracts 63, 16370c (1965).

ALBERT T. MEYERS, Primary Examiner F. E. WADDELL, Assistant Examiner 

